The Consortium

The mission of the Pre-medical Cancer Immunotherapy Network for Canine Trials (PRECINCT) is to provide infrastructure and oversight to a highly collaborative and interactive network of researchers and clinician scientists working to accelerate the application of next generation immunotherapies through comparative oncology.

Coordinating Center:

Collaborative Network:

The Coordinating Center at the University of Pennsylvania provides comprehensive project oversight, supervises all project management and regulatory compliance activities, and coordinates site management for all aspects of single and large multi-site projects in PRECINCT.

Principal Investigators:

 

Dr. Nicola J. Mason, Department of Clinical Sciences & Advanced Medicine at the University of Pennsylvania.

 

Dr. Qi Long, Department of Biostatistics, Epidemiology, & Informatics, Perelman School of Medicine at the University of Pennsylvania
 

PennVet Research

https://www.vet.upenn.edu/research/centers-initiatives/mason-immunotherapy-research

Contact for Clinical Trials Information: 

Natalie Kuzla, MA

nkuzla@pennmedicine.upenn.edu 
 

University of Pennsylvania Coordinating Center

 
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The Flint Animal Cancer Center at Colorado State University together with the Cummings Veterinary Medicine Center at Tufts University are conducting studies to assess the efficacy of combination immunotherapy approaches to treatment and prevention of tumor metastasis in dogs with osteosarcoma. These studies are being done in dogs with measurable osteosarcoma metastases, which will allow ready detection of treatment efficacy in a rapid time frame.

Project Synopses:

Optimizing Novel Immunotherapy Combinations Targeting the Tumor Microenvironment in Canine Spontaneous Osteosarcoma 

 

For Pet Owners:

Clinical Trials for Osteosarcoma Trial 1

Principal Investigators:

Dr. Steven Dow, veterinarian trained in immunology, microbiology, and cancer research, Flint Animal Cancer Center at Colorado State University

 

Dr. Cheryl London, veterinary medical oncologist trained in immunology, 
Cummings Veterinary Medicine Center at Tufts University
 

Flint Animal Cancer Center at Colorado State University
300 W Drake Rd.
Fort Collins, CO  80525

https://www.csuanimalcancercenter.org/

Cummings Veterinary Medical Center 
at Tufts University
200 Westboro Rd.
N. Grafton, MA 01536

vetmed.tufts.edu

Contact for Clinical Trials Information: 

csuoncologytrials@colostate.edu 
or call (970) 297-4001.

Colorado State University & Tufts University

 
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The Cummings Veterinary Medical Center at Tufts University is conducting studies in dogs with Diffuse Large B-cell Lymphoma (DLBCL) to develop novel immunotherapy strategies that are effective or better than current therapies. The work his to evaluate novel combinations of immunotherapies in dogs with previously untreated DLBCL to identify the most promising approach, and then evaluate this against standard CHOP chemotherapy in a prospective clinical trial. Ultimately, the goal is to develop an effective chemotherapy free regime for DLBCL that can be rapidly translated into subsequent human trials.

Project Synopses:

Enhancing the efficacy of immunotherapy in DLBCL using rational combination approaches.

For Pet Owners:

Clinical Trials in B-Cell Lymphoma

Principal Investigator:

Dr. Cheryl London, veterinary medical oncologist trained in immunology, 
Cummings Veterinary Medicine Center at Tufts University

 

Cummings Veterinary Medical Center 
at Tufts University
200 Westboro Rd.
N. Grafton, MA 01536

vetmed.tufts.edu

 

Contact for Clinical Trials Information: 

Cheryl London

614-915-7409

Cornell University & Tufts University

 
 
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Dr. M. Renee Chambers, DVM, MD, a neurosurgeon and veterinarian at The University of Alabama at Birmingham (UAB) - is partnering with veterinarians to conduct the first immunotherapy study for brain tumors in dogs using an oncolytic herpes simplex virus known as M032. The virus, developed at UAB, is currently being used in a clinical trial to treat humans with the same tumors. Care for pet dogs is now available at regional sites, including the Colleges of Veterinary Medicine at Mississippi State, Georgia and Auburn. This trial opens up an exciting new research pathway while providing the potential of a therapy that could benefit both humans and canines with brain tumors.

Project Synopses:

Canine ImmunoNeurotherapeutics

For Pet Owners:

Glioblastoma Clinical Trial 2

Principal Investigator:

Dr. M. Renee Chamber, DVM, MD, neurosurgeon and veterinarian

 

The University of Alabama at Birmingham

1720 2nd Avenue South 

Birmingham, AL 35294-3410

https://www.uab.edu/medicine/caninetrial/


Study and contact information: 
uab.edu/medicine/caninetrial 

or call (205) 975-7519

University of Alabama at Birmingham

Investigators at the UCDavis Comprehensive Cancer Center have teamed up with the UCDavis School of Veterinary Medicine to launch a series of investigative immunotherapy trials aimed at enhancing a patient's own natural killer cells using inhaled recombinant IL-15 and super-agonist IL-15 in naturally occurring canine cancers. The purpose of this study is to determine the maximum tolerated dose and efficacy of an immunotherapy protocol against metastatic osteosarcoma or melanoma growing within the lungs.

Project Synopses:

Enhancing natural killer immunotherapy with first-in-dog trials of inhaled recombinant IL-15 and super-agonist IL-15 in naturally occurring canine cancers.

 

For Pet Owners:

Clinical Trials for Malignant Melanoma

Clinical Trials for Osteosarcoma Trial 2

Principal Investigator:

Dr. Rob Rebhun; Maxine Adler Chair in Oncology

University of California Davis, School of Veterinary Medicine

Dr. Robert Canter; Professor of Surgery

University of California Davis, School of Medicine

 

University of California Davis,
School of Veterinary Medicine

944 Garrod Drive

Davis, CA 95616

Contact: oncologyclinicaltrials@ucdavis.edu

530-752-0125 or 530-752-9759

https://clinicaltrials.vetmed.ucdavis.edu/

University of California - Davis

Dr. Rob Rebhun

Dr. Rob Rebhun 

Maxine Adler Chair in Oncology

University of California Davis,

School of Veterinary Medicine

Dr. Robert Canter

Dr. Robert Canter

Professor of Surgery

University of California Davis,

School of Medicine

 
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The Veterinary Medical Center at the University of Minnesota is conducting a study in dogs with high-grade glioma including glioblastoma (GBM), common primary malignant brain tumors, to develop novel immunotherapy strategies that are more effective than current treatments. These tumors are uniformly deadly in both dogs and people with median survival times of a few months in dogs and approximately 14 months in people after standard of care treatment. This work aims to evaluate novel combinations of immune therapies in dogs with previously untreated brain tumors to determine the combination that provides the longest remission times with minimal adverse effects. Our ultimately goal is to develop a safe and effective postoperative treatment that avoids the standard chemotherapy and radiation therapy that can be translated into human GBM patients.

Project Synopses:

Novel combined immunotherapeutic strategies for glioma: using pet dogs as a large animal spontaneous model.

 

For Pet Owners:

Glioblastoma Clinical Trial 1

Principal Investigator:

Dr. Liz Pluhar (PI), veterinary surgeon trained in neurosurgery,

Veterinary Medicine Center at the University of Minnesota

Dr. Michael Olin (co-PI), veterinary immunologist

Developing vaccine-based immunotherapies,

Masonic Cancer Center at the University of Minnesota

 

Dr. Maria Castro (co-I), research scientist in neuroimmunology

Developing viral-mediated gene therapies,

Medical School at the University of Michigan. 

The Veterinary Medical Center at

the University of Minnesota

1365 Gortner Ave,

St Paul, MN 55108

 

Contact for Clinical Trials Information: 

Dr. Elizabeth Pluhar

pluha006@umn.edu

University of Minnesota

 

© 2019 PRECINCT | PennVet | Philadelphia, PA | 215-573-2935

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