Addressing Common Misuses and Pitfalls of P values in Biomedical Research

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response

Robert B Rebhun, Daniel York, Sylvia Margret Cruz, Sean J Judge, Aryana M Razmara, Lauren E Farley, Rachel V Brady, Eric G Johnson, Jenna H Burton, Jennifer Willcox, Luke A Wittenburg, Kevin Woolard, Cordelia Dunai, Susan L Stewart, Ellen E Sparger, Sita S Withers, Alicia A Gingrich, Katherine A Skorupski, Sami Al-Nadaf, Amandine T LeJeune, William Tn Culp, William J Murphy, Michael S Kent, Robert J Canter

Journal for ImmunoTherapy of Cancer 2022;10:e004493. doi: 10.1136/jitc-2022-004493

Losartan Blocks Osteosarcoma Elicited Monocyte Recruitment, and Combined with the Kinase Inhibitor Toceranib, Exerts Clinical Benefit in Canine Metastatic Osteosarcoma

Losartan Blocks Osteosarcoma Elicited Monocyte Recruitment, and Combined with the Kinase Inhibitor Toceranib, Exerts Clinical Benefit in Canine Metastatic Osteosarcoma

Daniel P Regan, Lyndah Chow, Sunetra Das, Laurel Haines, Eric Palmer, Jade N Kurihara, Jonathan W Coy, Alissa Mathias, Douglas H Thamm, Daniel L Gustafson, Steven W Dow

Clinical Cancer Research 28(4):clincanres.2105.2021

DOI:10.1158/1078-0432.CCR-21-2105

Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing Il-12, in pet dogs with sporadic gliomas

Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing Il-12, in pet dogs with sporadic gliomas

Nidal B. Omar MD, R. Timothy Bentley BVSc, David K. Crossman PhD, Jeremy B. Foote DVM, PhD, Jennifer W. Koehler DVM, PhD, James M. Markert MD, MPH, Simon R. Platt BVM&S, Daniel R. Rissi DVM, MS, PhD, Andy Shores DVM, MS, PhD, Donald Sorjonen DVM, MS, Amy B. Yanke DVM, MS, G. Yancey Gillespie PhD, and Melissa R. Chambers DVM, MD

Neurosurg FocusVolume 50 • February 2021. DOI: 10.3171/2020.11.FOCUS20844.

Minimal PD-1 expression in mouse and human NK cells under diverse conditions.

Minimal PD-1 expression in mouse and human NK cells under diverse conditions.

Judge SJ, Dunai C, Aguilar EG, Vick SC, Sturgill IR, Khuat LT, Stoffel KM, Van Dyke J, Longo DL, Darrow MA, Anderson SK, Blazar BR, Monjazeb AM, Serody JS, Canter RJ, Murphy WJ.

J Clin Invest. 2020 Jun 1;130(6):3051-3068. doi:10.1172/JCI133353. PMID: 32134744 PMC7260004 (available on 2020-09-01).

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer.

Blood and tissue biomarker analysis in dogs with osteosarcoma treated with palliative radiation and intra-tumoral autologous natural killer cell transfer.

Judge SJ, Yanagisawa M, Sturgill IR, Bateni SB, Gingrich AA, Foltz JA, Lee DA, Modiano JF, Monjazeb AM, Culp WTN, Rebhun RB, Murphy WJ, Kent MS, Canter RJ.

PLoS One. 2020 Feb 21;15(2):e0224775. doi:10.1371/journal.pone.0224775. eCollection 2020. PMID: 32084139 PMC7034869. Clinical Trial.

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence.

Characterizing the Dysfunctional NK Cell: Assessing the Clinical Relevance of Exhaustion, Anergy, and Senescence.

Judge SJ, Murphy WJ, Canter RJ.

Front Cell Infect Microbiol. 2020 Feb 13;10:49. doi:10.3389/fcimb.2020.00049. eCollection 2020. PMID: 32117816 PMC7031155. Review.

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy.

Characterization and Potential Applications of Dog Natural Killer Cells in Cancer Immunotherapy.

Gingrich AA, Modiano JF, Canter RJ.

J Clin Med. 2019 Oct 27;8(11):1802. doi:10.3390/jcm8111802.

PMID: 31717876 PMC6912828. Review.

Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma.

Metastatic immune infiltrates correlate with those of the primary tumour in canine osteosarcoma.

Withers SS, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Burton JH, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB.

Vet Comp Oncol. 2019 Sep;17(3):242-252. doi:10.1111/vco.12459. Epub 2019 Apr 8.

PMID: 30684301 PMC6658355 (available on 2020-09-01)

Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma.

Association of macrophage and lymphocyte infiltration with outcome in canine osteosarcoma.

Withers SS, Skorupski KA, York D, Choi JW, Woolard KD, Laufer-Amorim R, Sparger EE, Rodriguez CO, McSorley SJ, Monjazeb AM, Murphy WJ, Canter RJ, Rebhun RB.

Vet Comp Oncol. 2019 Mar;17(1):49-60. doi:10.1111/vco.12444. Epub 2018 Sep 19.

PMID: 30156029 PMC6363827.

Multi-color flow cytometry for evaluating age-related changes in memory lymphocyte subsets in dogs.